Evaluation of Standardized Extract of Centella Asiatica on Cell Viability and Repressive Cancer Migration in Metastatic Colorectal Cancer Cells in Vitro

Centella Asiatica has been traditionally used as herbal medicine to treat various disorders, such ulcers and psoriatic disease. ECa233 is an extract of containing madecassoside (46.3 %) asiaticoside (41.6 that shows a highly acceptable safety profile appropriate for drug development use humans. 5-fluorouracil (5-FU) chemotherapeutic agent generally known the first-line chemotherapy colorectal cancer. Representative combined with 5-FU, namely FOLFOX regimen (5-FU, leucovorin, oxaliplatin), widely in hospitals typically selected prescriptions. However, unresolved problems appearing clinical situations are refusal accept leading resistance severe side effects after being administered intravenously entire body. Therefore, discovery novel pure standard enhance efficacy 5-FU overcome this still needs be explored. To assess pharmacological activity major goal cancer discovery. was evaluated its anti-cancer, anti-migration, anti-invasive activities explored regarding data on normal cells. The results demonstrated effectively inhibited cell viability, colony forming, truly inactivated migration/invasion through repressive MMP-9 invasive factor. Pharmacological interaction synergism cells safe growth. suggest could combinative therapy treatment other medicinal drugs targeted patients.